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Modern ideas about the cellular mechanisms of organic nitrate action are reported. The mechanisms of tolerance and withdrawal syndromes developing at nitrate administration are described. Treatment schemes aimed at prevention of these phenomena are suggested.

Literature data and the findings of the original research of the role of profibrogen factors in forming cardiac and renal disorders in arterial hypertension are analyzed and generalized.

The literature data about the possible causes of cardiac arrhythmia development in patients with mitral valve prolapse are featured. The urgency of the issue is shown. The authors conclude about the necessity of further investigation of dysrhythmia pathogenesis in these patients for timely distinguishing the risk group of complication development.

Modern ideas about the epidemiology, clinical manifestations, collagen biosynthesis peculiarities, and diagnosis of non−differentiated connective−tissue dysplasia in children are featured.

Modern data about family conflicts and the associated spouse deadaptation are discussed. The author concludes about the necessity of further investigation of the issue.

The causes and mechanisms of spouse deadaptation when the husband suffers from organic personality disorders are shown. The obtained data allow development and administration of pathogenetically targeted psychotherapeutic correction.

The methods of psychodiagnosis were used to reveal the regularities of interpersonal adaptation disorders in spouses at long−term sequelae of military closed brain injury in the husband.

An effective scheme of psychotherapeutic correction of sexual deadaptation developing in the debut of the sexual life due to disorders of sex−role behavior in one or both spouses is presented.

Current opinions about the mechanisms of forming erectile dysfunction in patients with diabetes mellitus are presented. The authors conclude about the leading role of androgens in development of this pathology.

The causes, mechanisms of forming and clinical picture of pathological masturbation in men with specific personality disorders are shown. The author concludes about the necessity to consider the revealed regularities in psychotherapeutic correction of the studied pathology.

The degree of Parkinson's disease progress was evaluated based on a complex analysis of age−associated peculiarities of the clinical signs against a background of pathogenetic therapy. Side effects of main classes of anti−Parkinsonian drugs at many−year administration at different stages of the disease were analyzed.

New literature data and the original experience of observation of the patients with manganese toxic encephalopathy are presented. A pathogenetically substantiated scheme of this disease treatment was suggested.

The paper covers the perinatal aspects of iodine deficiency states. The urgency of the issue is shown.

The urgency of the problem of labor activity regulation is shown. Significance of a new group of drugs (calcium antagonists) which has not been used yet with the purpose to reduce the uterus contractions is shown.

Modern data about the causes of male sterility and its association with sexually transmitted diseases are presented. The pathogenesis, diagnosis and approaches to treatment of this pathology are discussed.

The data about the mechanisms of programmed cell life are reported. It was shown that the efficacy of male sterility treatment is determined by a dynamic interrelation of apoptosis and cryo−renewal (its shift to cryo−renewal).

The etiology, injury mechanisms, classification, diagnosis, differential treatment and prognosis in closed kidney injury are discussed. An insufficient elaboration of some aspects of the problem is shown.

The authors report the experience of angiographic diagnosis and x−ray surgery for liver lesions. The necessity and efficacy of endovascular hemostasis are shown.

The difficulties of differential diagnosis of drug diseases with pseudoallergic and toxic reactions, false polyvalence and pharmacophobias are shown. Main diagnostic criteria are reported. The disadvantages of skin tests are described. Their significance for differential diagnosis of specific immunological and biophysical diagnosis is emphasized.

The results of the study of circadian biorhythms of hormones (cortisol and insulin) in the blood and adaptation capabilities of the patients with chronic eczema are presented. The advantages of the drugs limiting stress−reaction (dalargin) and increasing adaptation capabilities of the organism (melatonin) are shown vs traditional drugs used in this disease.

The data about bird flue, its etiology, peculiarities of epizootiology, epidemiology, clinical picture in humans and birds are presented. The features of the disease diagnosis are shown. The possibilities of a new flu pandemic are featured.

Peripheral blood mononuclear cells were studied in children with various forms of tuberculosis and non−infected children for DNA of M. tuberculosis, Epstein−Barr virus, and type VI human herpes virus as well as for humoral immune response to these microorganisms. Considerable differences between the groups were revealed in the immune response to various antigens of Epstein−Barr virus.

Two−dimensional and pulsed Doppler echocardiography were used to show the possibility disturbances in transmitral blood flow, partially representing the diastolic function of the left ventricle, in a group of patients with abnormal chords as to their type: amount, location, thickness.

The capabilities of radiodiagnosis (radiography, computed tomography, magnetic resonance imaging) at knee joint injuries are discussed.

The principles and ways of development of family medicine are featured. The information about the work of 2nd Ukrainian Congress of General Practitioners (Family Doctors) is presented.

The findings of the study and objective evaluation of the working time use by the directors of centers for hygiene and epidemiology (Baku) are reported. Scientifically validated recommendations on rational use of the working time by the managers of the establishments for sanitary−epidemiological service are given.Информация о международном семинаре "атеротромбоз и инсульт: современные подходы к профилактике и лечению"