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The authors report the results of investigation of criminal behavioral activity in persons with paraphilias imprisoned for sexual crimes as well as the original typology of their criminal activity.

Main principles and methods of the system of psychotherapeutic correction of spouse, in particular primary, sexual disadaptation at neurotic depressions in women are described. A high therapeutic effect obtained when using the original system in the clinical practice is shown.

Investigation of the patients with neurological complications of primary hypothyrosis revealed a pathogenetic role of metabolic homeostasis disorders in forming these complications as well as dependence of dynamics of metabolic changes in the disease etiology.

The mechanisms of disorders in the immune−neuroendocrine regulation at various clinical forms of arterial hypotension are described. The choice of the tactics of individual treatment is substantiated.

The authors review the literature on the problem of arterial hypertension and its association with metabolic syndrome. The mechanisms responsible for constant increase of AP, peculiarities of hemodynamics and involvement of the target organs at the investigated pathology are featured.

The data about the incidence of different arrhythmias, interaction of some rhythm disorders and clinical hemodynamic parameters in patients with hypertrophic cardiomyopathy are reported.

Blood plasma leukotriene C4 level as well as its association with structural functional state of the myocardium were investigated in acute heart failure. A positive effect of treatment of this disease with water−soluble inhibitor of 5−lipoxigenase Quercetin is shown.

Significance of stress and its character in stratification of the general cardiovascular risk in patients with arterial hypertension is discussed. It is emphasized that stress associated with the health, stress of affective connections and occupational life considerably worsen the prognosis of this disease.

The factors influencing the outcome of treatment for bronchial asthma are featured. It is shown that adherence of the patients to drug therapy is of principal significance for the outcome of the treatment.

The literature data about pregnancy miscarriage with the outcome to non−developing pregnancy are reviewed. Insufficient work on this problem has been noted.

The data about the capabilities of ultrasound dopplerometry of uterine arteries in pregnant with the purpose of prognosis of premature birth, pre−eclampsia, preterm detachment of normally located placenta, incapability of the post−operative scar of the uterus are reported. The values of disturbance of the indices of vascular resistance at increased risk of definite obstetric complications were determined.

The original method of systemic structural analysis which includes all aspects of reproductive health and is the basis of interdisciplinary diagnosis and adequate complex therapy of its changes is presented.

Methods of surgical correction of syndrome of compression of vascular formations, embolization, suppuration, involvement of the lymph vessels and pelvic bones in local tumors of the small pelvis are reviewed and analyzed. The 10−year experience of the authors of treatment for this pathology in 147 patients is generalized. Main methods of surgery are classified and analyzed.

The peculiarities of treatment for acute empyema of the pleura with the use of thoracoscopic techniques are featured. The techniques of pleural cavity drainage under thoracoscopic guidance as well as thoracoscopic lung decortication are described. Good results of this therapeutic tactics were noted.

Up−to−date literature about the use of type A botulinum toxin in treatment of urological diseases, in particular urinary bladder hyperactivity and prostate adenoma, is reviewed. A high efficacy of Dysport and Botox is shown. Injection technique of their administration is described in detail. The prospects of this method in clinical practice are shown.

Contemporary data about the possibility of thyroid carcinoma development against a background of thyroid pathology are presented. Risk groups of thyroid carcinoma development were determined. A diagnostic algorithm of timely and early diagnosis of thyroid carcinoma was worked out. Therapeutic approaches to prevention of thyroid cancer are suggested.

The role of ultrasound investigation, computed tomography, magnetic resonance imaging, positron emission tomography in diagnosis of regional metastases of germentative testicular tumors is discussed. The advantages and disadvantages of each method are described.

The information about the etiology, pathogenesis, clinical manifestations of the commonest types of paraneoplastic dermatosis is presented.

Modern literature and the original data about psoriasis etiopathogenesis are analyzed. The capabilities of differentiated approach to treatment of the patients with the consideration of the stage and severity of the process are featured.

Both literature and original data about clinical laboratory and complex ultrasound diagnosis of combined thyroid and genitourinary pathology are reported.

The literature data on the morphological substrate of spinal artery syndrome are analyzed.

The literature data on the influence of synthetic and natural antioxidants − ascorbic acid, tocopherol, superoxide dismutase, catalase, N−acetylsistein etc. on phagocytosis are reviewed. The mechanisms of antioxidants action on phagocytosis are featured.

Biochemical and clinical substantiation of the use of multikinase inhibitor Sorafenib in treatment of cancer of the liver and kidneys are discussed.

The results of the analysis of the phenomenon of limited ability to integrate to the community of the patients with mental disorders are presented. Medico−social and psychological aspects of this problem are featured.

The data on the achievements of specific prevention in the fight against infectious diseases and dangers of anti−vaccination movement are reported. The authors conclude about the urgency of immune prevention and reversibility of the achieved epidemic well−being in case of disturbances or cessation of immune prevention programs.