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The findings of investigation of cognitive function, life quality and depression level in patients with extracranial vascular pathology are reported. Considerable decrease in the level of the life quality as well as most pronounced cognitive deficiency and depression level were revealed at occlusive lesions of internal carotid arteries as well as at multifocal extracranial stenoses.

Medical−psychological investigation of the peculiarities of emotional sphere in patients with the most common variants of chemical addiction was performed. The findings of the research, which gave ground for formation of interventional treatment of these groups, are described. Main pathopersonological peculiarities of the persons with different forms of chemical addiction are featured. The association of addiction and premorbid personality peculiarities was determined.

The data about the clinical picture, course and integrated approach to the problem of control of withdrawal syndrome of a new type of addiction to antidepressant Coaxil (tianeptinum) are presented. The original approach to treatment of Coaxil addiction considers the revealed aspects of the pathogenic effect of the drug on the mental and somatoneurological sphere of the addict.

Two algorithms of pseudoabstinence syndrome prognosis in patients with opioid addiction, using the system of discriminate equations and method of quantification of the degree of pathopsychological and clinical signs with determining the greatest values of Kullback divergence, were worked out. Higher efficacy of the algorithm made using Kullback method was shown.

The necessity of differential approach to diagnosis of the main disease and therapeutic measures was shown, based on the review of the data about vertebral canal stenosis.

The use of vegetable oils in treatment of type 2 diabetes mellitus against a background of hypolipidemic therapy with Lipanor was investigated. Efficacy of corn oil in the daily diet of the patients with this disease was demonstrated.

The peculiarities of artery remodeling at physiological aging and in elderly with arterial hypertension are described. The findings of investigation of structural functional properties of the arteries with the use of modern techniques in persons over 60 with various pathogenic variants of hypertension are reported. The capabilities of medical correction of arterial rigidity are featured.

An algorithm of choice of the volume of surgical correction of obstructive hypertrophic cardiomyopathy considering multifunctional changes and pathophysiological mechanism of the obstruction was worked out. The efficacy of different variants of surgical treatment is shown.

Literature analysis allowed to demonstrate, that cerebral natriuretic peptide could be a marker of heart failure (HF) diagnosis in patients with acute coronary syndrome (ACS) (systolic and diastolic variant) as well as a marker of ischemic prevalence, which influences long− and short−term prognosis of ACS in respect to survival, development of repeated coronary events and HF.

The literature data about sarcoidosis are generalized with the account of the authors' many−year experience accumulated at observation of the patients with sarcoidosis. Respiratory organ sarcoidosis and extrapulmonary sarcoidosis of the organs, involvement of which can cause emergency states, are described.

The world and Ukrainian scientific achievements in the area of the use of bacterial immunomodulators and specific immunotherapy for polypous rhinosinusitis are reported.

The lesions of hearing apparatus in patients with acute herpes virus neuroinfection are characterized. It is shown, that various types of herpes viruses involve specific for this virus areas of auditory analyzer. Dependence of the administered drug on the type of the agent and level of the hearing apparatus involvement was proven for effective treatment of these diseases.

The risk factors and their influence on the frequency of relapses of duodenal peptic ulcer in patients with hypothyroidism were investigated. It was established, that the disease relapses are determined not only by a complex of social factors, but also the level of thyroid function, which should be taken into consideration in clinical practice.

The incidence of complications in patients with gastric and duodenal ulcer is described. It is shown, that at prolonged conservative therapy the age of operable patients increased, the incidence of accompanying diseases or their combinations increased, which required a goal−oriented approach at preparation of this severe category of patients to the operation, the choice being resection for radical treatment of ulcer.

Modern literature data as well as the original findings about the course and outcomes of pregnancy in women with congenital heart defects are reported. Main types of defects, which frequently occur in pregnant, are analyzed. Risk factors for the mother and fetus are featured.

The influence of immunocorrecting therapy with drugs made from placenta extraction and Cryocell−palcenta cryoextraction was investigated. It was determined, that placenta drugs promoted normalizing cellular immunity disorders in the peripheral blood and follicular fluid, but cryoextraction of placenta possessed more pronounced effect on the state of cellular immunity in patients with tuboperitoneal infertility. It is recommended to use cryoextraction of placenta at preparation to extracorporeal ferti−lization with the purpose of immunocorrection in patients with infertility caused by chronic diseases of the small pelvis.

Ultrastructure reconstructions of the intracellular structures and organelles of the cells of the vascular wall were investigated. The causes of forming thrombi in the vessels of the veins of lower extremities were determined at ultrastructure level.

Investigation of the dynamics of synthesis of main regulatory cytokines in patients with viral hepatitis depending on the virus genotype was investigated. The obtained findings allowed to recommend complex investigation of the patients with hepatitis A with determining the markers of active replication of viral ribonucleic acid as well as the level of main regulatory cytokines.

Contemporary ideas about the role of Bartonella henselae and Bartonella quintana in development of bacillary angiomatosis are presented. Different clinical variants of infection as well as the methods of their diagnosis, treatment and prevention are featured.

The findings of comparative analysis of the levels of proinflammatory (TNF−α, IL−1, IL−6) and antiinflammtory (IL−4, IL−10) cytokines in the cerebrospinal fluid of the patients with purulent and serous meningitis are presented. Increased concentration of both proinflammatory and antiinflammtory cytokines was revealed.

The data about the etiology, pathogenesis and clinical picture of secondary deforming osteoarthrosis, ankyloses of temporomandibular joint as well as surgical treatment of ankylosis of temporomandibular joint with a new two−pole endoprosthesis with a distraction device are reported. Clinical examples of the patients with bilateral and unilateral bone ankylosis are given.

The use of root canal filling with master pin and composite sealant Citofil−Ca is substantiated. Radiography and clinical examination were used to demonstrate a high efficacy of the performed obturations.

For the first time complex experimental research of a maternity hospital was done within the program of monitoring the prevalence of nosocomial strains. The etiological structure and biological properties of conventionally pathogenic microorganisms were determined. The expediency of application of differential diagnosis, selective media and microtest systems for their indication and identification at bacteriological diagnosis of purulent−septic diseases was substantiated experimentally.