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№2' 2013

QUESTIONS OF IMMUNOGENESIS

International Medical Journal, Vol. 19., Iss. 2, 2013, P. 106−110.

IMMUNOLOGICAL ASPECTS OF LIPID METABOLISM IN PATIENTS WITH NEPHROTIC SYNDROME

National University of Pharmacy, Kharkiv, Ukraine

Abstract. Urgency of investigation of chronic glomerulonephritis is connected with the fact that the course of this disease is characterized by stable progress, the process gradually results in renal tissue sclerosis and loss of its function. Clinical laboratory methods were used to investigate the character and role of immunological features of lipid metabolism disorders in the pathogenesis of nephrotic syndrome in patients with chronic glomerulonephritis. The results of the study of lipoprotein−containing immune complexes in patients with chronic glomerulonephritis with nephrotic syndrome without it are reported. The study demonstrated improvement in LDLP−IgA and reduction in LDL?P−IgG in all patients, most pronounced in those with nephrotic syndrome, which also had elevated levels of LDLP−IgM. The possible mechanisms of influence of lipoprotein−containing immune complexes on glomerular changes in chronic glomerulonephritis were described. The association between the level of LDLP and proteinuria development, and the changes in glomerular filtration rate is shown.

Key words: chronic glomerulonephritis, nephrotic syndrome, lipoprotein−containing immune complexes.