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№2' 2013
HYGIENE, EPIDEMIOLOGY, MEDICAL ECOLOGYInternational Medical Journal, Vol. 19., Iss. 2, 2013, P. 111−115.
INFLUENCE OF HEPATITIS A IN THE PERIOD OF RECOVERY ON MAINTAINING POST-VACCINATION IMMUNITY TO DIPHTHERIA
Kharkiv Medical Academy of Post−graduate Education, Kharkiv, Ukraine
Abstract. The state of active artificial antitoxic antidiphtheria immunity was investigated in children aged 1−14 with the history of viral hepatitis A during 6 months of convalescence. The level of titers of specific antibodies to diphtheria in the peripheral blood was determined. The investigation of the level of active artificial antitoxic immunity to diphtheria was done using passive hemagglutination reaction. The influence of viral hepatitis A in the period of convalescence on the state of active artificial antitoxic immunity to diphtheria was investigated in previously vaccinated children. Significant reduction of antibody titers to diphtheria agent in the period of convalescence in children with the history of viral hepatitis A compared with clinically healthy children of all ages was revealed. It was found out that the level of active artificial antidiphtheria immunity in the period of hepatitis A convalescence was characterized by dynamic changes depending on the age of the children and initial state of their immunity. In particular, it was proven that the presence of non−protective antibody titers in children aged 7−14 years with hepatitis A was observed 6 months after the discharge from the hospital; the proportion of patients with non−protective antibody titers was 52.0%. Recovery of antibody levels occurred only 6 months after the onset of the disease, but before that time it did not reach the initial level.
Key words: hepatitis A, convalescence period, diphtheria, vaccinations, specific immunity strain, children.