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№2' 2013

PEDIATRICS

International Medical Journal, Vol. 19., Iss. 2, 2013, P. 25−28.

CHRONIC KIDNEY DISEASE IN CHILDREN: SUPRANOSOLOGICAL AND NOSOLOGICAL APPROACHES

Kharkiv National Medical University, Kharkiv, Ukraine

Abstract. The concept of chronic kidney disease (CKD) does not eliminate the nosological approach to the diagnosis of the disease. CKD suggests the likelihood of adverse outcomes that are measured risks. The main CKD risk is renal process progress with chronic renal failure (CRF) development. It becomes clear that early diagnosis of the causal nosology and the nosological adequate therapeutic management are very important. The aim of the work was to explore the features of the nosological structure of the urinary system in CKD children with the progress towards end−stage of CRF. Clinical data of 222 children aged 7−17 with nondiabetic CKD were studied. The nosological structure analysis of urinary system pathology in CKD patients was carried out. It was established that congenital anomalies of the urinary system prevailed in the nosological structure in CKD children. It was demonstrated that congenital and hereditary nephropathies dominated over acquired nephropathies. It was determined the relative increase of the glomerular diseases proportion in the nosological structure in children with stage III−IV CKD was due to the most unfavorable variants according to the forecast. The necessity of nosological approach to the disease diagnosis in the individual child was proved for determining the effective therapeutic program aimed at prevention of CKD or deceleration of its progress towards end−stage of chronic renal failure.

Key words: chronic kidney disease, children, nosology.