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Dynamics of membrane−bound enzymes activity changes in the blood of 67 patients with multiple sclerosis was investigated depending on the variety and duration of the disease. It was noted that the most pronounced enzymatic dysbalance was observed in patients with cerebrospinal multiple sclerosis and in patients with the disease duration over 10 years, which is a marker of disease severity and degree of the pathological process generalization. Decreased CPK level in patients with all varieties of the disease, regardless of multiple sclerosis duration, reflects the degree of reduction of metabolic and energy processes rate in the cells of muscular and nervous tissues, possibly due to increased catabolism and, as a consequence, development of movement disorders.

The literature data on significance of the problem of thromboembolic complications in patients with non−valve atrial fibrillation, about the features of anticoagulation therapy in this pathology and difficulties occurring at choice of medication for prevention of thromboembolic complications are presented.

The article discusses the results of a study on the effectiveness of combination antihypertensive therapy in patients with diabetic nephropathy based on the dynamics of hemodynamic and metabolic parameters in patients with different responses in blood pressure to load with salt. Effectiveness of combined antihypertensive therapy was significantly more pronounced in salt−sensitive patients.

Various hypotheses about the etiology of cancer of esophagogastric junction, its relationship with gastroesophageal reflux disease are presented.

Pathogenetic mechanisms of L−carnitine effect in nonalcoholic fatty liver disease are highlighted. The data on treatment of patients with nonalcoholic steatohepatitis using Hepadif in complex the−rapy are reported.

The efficacy and safety of Dietressa application in patients with comorbid gastroenterological diseases (high body mass index or grade 1−2 obesity against a background of gastroesophageal reflux disease, nonalcoholic fatty liver disease) were determined. It was noted that the drug affects the eating behavior of the patients via endocannabioid−dependent CB1 receptors contributing to reduction of their body weight.

The experience of treating patients with locally advanced gastric cancer in which gastroplasty with ileocecal segment of the intestine was performed during combined gastrectomy was analyzed. It was noted that this method was not accompanied by severe injury, increase in the time of surgery, and postoperative complications. Gastroplasty with ileocecal segment promoted reduction of the number of long−term postgastrectomy syndromes and improved the quality of life of the patients.

Electron microscopy of peritoneal mesothelial cells in patients with adhesive peritoneal disease complicated with acute intestinal obstruction showed the presence of dystrophic, destructive and often degenerative disorders of organelles and intercellular membrane structures. Significant changes were observed in the mitochondria, suggesting inappropriate intracellular bioenergetics, resulting from development of mitochondrial dysfunction. The presence of metabolically active mesotheliocytes indicates the action of reserve intracellular repair mechanisms.

The major malformations of the fetus are presented. The questions of teratogenesis, teratogenic factors leading to appearance of malformations as well as influence of drugs on the fetus are discussed.

Morphological examination of placentas of 119 pregnant, of them 86 with the diagnosis of fetal growth retardation syndrome, was performed. It was noted that ultrasonography did not allow to estimate the degree of maturity of villous tree, but reflected maturity of the placenta as an organ on the whole. It was emphasized that at investigation of fetal growth retardation syndrome it is ne−cessary to pay attention to the factors determining maternal blood supply of the placenta, the most characteristic of which is disorder of blood circulation in the artery of the umbilical cord.

The features of the clinical manifestations of cervical ectopia (numerous signs, early sexual debut, low frequency of using barrier methods of contraception, the existence of 2 or more partners) and risk factors of the pathology development were characterized. The efficacy of laser Doppler flowmetry and combined therapy of patients with cervical ectopia.

The findings of a complex treatment of pelvic inflammatory disease in women of reproductive age, of them some had chronic hepatobiliary pathology, are presented. The efficacy of medication therapy including Zoxicef was demonstrated. Given the pharmacokinetics and pharmacodynamics of the drug, its priority use is possible in patients with diseases of the hepatobiliary system.

The analysis of hemodynamic disorders in the vertebral artery was made with the help of Doppler ultrasound in 28 patients with traumatic deformation of the cervical spine. Their dependence on the character of the primary damage, deformity volume and terms was revealed.

The results of surgical treatment of spine pathology (degenerative lumbar scoliosis, spondylolisthesis, spinal stenosis, uncomplicated compression fractures of vertebra) against a background of osteoporosis and aggressive hemangiomas using a universal device for bone cement introduction and cannulated screws are reported.

An optimized scheme of neoadjuvant chemotherapy in combination treatment of generalized stage III−IV ovarian cancer was suggested. The efficacy of its application in combination treatment vs. the traditional method was shown. The findings suggest that this method reduces the frequency of tumor recurrence and increases the period of remission in the first two years after the treatment.

The problem of the use of target drugs in metastatic renal cancer, administration of which is indicated at cytokine ineffectiveness, is discussed. It was noted that the choice of target drug is based on MSKCC criteria and factors of tumor process imaging (CT, MRI, ultrasonography). Additional selection criteria for a target drug as well as treatment control are under development.

The patients with infectious mononucleosis diagnosed with acute myocarditis were included in the study. A scheme of medication treatment including antiviral and metabolic drugs influencing the inflammatory, autoimmune and allergic processes, hemodynamics, symptomatic therapy for complications was suggested.

The study involved medical professionals with chronic hepatitis C accompanied by constant or periodic exacerbations with severe intoxication, morphological liver damage and a decrease in its functional capacity.

A comparative study of antimicrobial peptides, defensin (HNP), protein increasing permeability of membranes (BPI), and endotoxin in β−thalassemia was done. Biochemical (direct and indirect bilirubin, alkaline phosphatase, hemoglobin, ferritin, AST, ALT, mean corpuscular volume (MCV)) and immunoenzyme indicators (IgA, IgM, IgG, phagocytic activity) were determined. It was noted that increased level of endogenous antimicrobial peptides was a marker of infectious process and reflected the dynamics of the changes in biochemical parameters and immune status of the organism.

Infertility treatment is regarded as a reserve for increasing the population reproductive capacity. The efficacy of in vitro fertilization is estimated by the ratio of the number of successful attempts and the total number of attempts. It is emphasized that strictly coordinated hormonal control of the functions of immune cells is an absolute prerequisite for successful implantation, thus quantitative analysis of reception of estradiol and progesterone in the cells of mononuclear fraction in peripheral blood in periimplantation period is relevant.