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№2' 2014
CLINICAL PHARMACOLOGYInternational Medical Journal, Vol. 20., Iss. 2, 2014, P. 104−108.
EVALUATION OF SEX STEROIDS RECEPTORS EXPRESSION IN BLOOD MONONUCLEAR CELLS TO FORECAST THE EFFECTIVENESS OF IN VITRO FERTILIZATION
N.I. Pirogov Russian Research Medical University
Clinical City Hospital No. 31, Moscow, Russian Federation
The problem of artificial reproduction methods is urgent for Russia as the number of infertile couples exceeds 15%, which is critical of the demographic situation in the country. The effectiveness of IVF was assessed as the ratio of successful attempts to the total number of attempts. Strictly coordinated hormonal control of the functions of immune−competent cells is vital for successful implantation. The process of the embryo implantation depends adequate work of female sex hormones (estradiol and progesterone), at that receptivity is more important than their absolute amount. Estradiol increases synthesis of the proper receptors as well as progesterone, androgen receptors, while progesterone inhibits. An important role in prevention of abortions and pregnancy maintenance at the early stages is played by influence of progesterone on the receptors, therefore this hormone is administered with a preventive purpose. The findings of the clinical trial are controversial therefore it is important to determine practicability and efficacy of hormonal therapy to prepare the patients to in vitro fertilization.
Key words: infertility, in vitro fertilization, estradiol and progesterone receptors, implantation.