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№3' 2014

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 20., Iss. 3, 2014, P. 92−96.


Some aspects of pathogenesis of fibrocystic breast disease with prevalence of cystic component


Siniavina L. V.

Kharkiv Regional Clinical Oncology Center, Ukraine

The purpose of the study was to determine the level of sex steroids in the blood serum and contents the breast cysts in patients with the diffuse form of fibrocystic mastopathy with the prevalence of cystic component; to develop tactics of treatment for this pathology. The study involved 69 patients with fibrocystic mastopathy and 48 healthy women aged 23−65. Depending on the age and menstrual function main group of patients was divided into the following subgroups: 1a − 20 women with preserved menstrual cycle aged 23−35, 1b − 28 patients with preserved menstrual cycle aged 36−45, 1c − 21 perimenopausal or menopausal patients over 46. Serum hormone levels (prolactin, progesterone, estradiol, cortisol, thyroid−stimulating hormone), estradiol to progesterone ratio were determined in all patients. In single−walled cysts over 10 mm in diameter puncture with evacuation of the contents was performed. Concentration of progesterone and estradiol was assessed in the cystic contents. No significant hormonal changes were revealed in subgroup 1a, more pronounced changes were present in the hormonal status of subgroup 1b and no significant difference in the content of hormones were found in subgroup 1c. Absence of marked changes in the content of hormones in the blood serum in subgroup 1c confirms that at this age metabolic abnormalities leading to cystic breast tissue degeneration play more important role. The patients with macrocystic changes in the breast tissue demonstrated marked accumulation of estradiol in the cystic content (645.58±298.53 ng/ml) with absence of absolute hyperestrogeny. The identified changes in the level of estradiol in breast cystic content confirm the information about local metabolic disturbances in the breast tissue in proliferative processes.

Key words: fibrocystic breast disease, macrocysts, hormone levels, treatment.


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