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№1' 2015
OPHTHALMOLOGYInternational Medical Journal, Vol. 21., Iss. 1, 2015, P. 92−95.
DYNAMICS OF THE RETINAL NERVE FIBERS LAYER THICKNESS IN THE INFERIOR QUADRANT IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA, TREATED BY L-ARGININE
Kharkiv National Medical University, Ukraine
The aim of this study was to determine the dynamics of the retinal nerve fibers layer thickness in the inferior quadrant in patients with primary open−angle glaucoma (POAG), treated by L−arginine. The study involved 162 patients (287 eyes) with POAG. The study group consisted of 82 patients (146 eyes) who received basic therapy along with L−arginine (patent of Ukraine UA 52177 U). The control group included 80 patients with POAG (141 eyes) who received standard therapy. It was found that the frequency of stabilization the retinal nerve fibers layer thickness in the inferior quadrant was observed 1.5 times more frequently (65.1 %) compared with the control group (42.5 %, p < 0.05). The frequency of stabilization the retinal nerve fibers layer thickness in the inferior quadrant in patients with POAG significantly increased at the first stage (21.2 % vs. the control group, while in the second stage by 21.9 %. It was established that application of L−arginine in treatment of patients with POAG helped to stabilize the retinal nerve fibers layer thickness in the inferior quadrant. Thus, in the control group there was a significant decrease in the retinal nerve fibers layer thickness in the inferior quadrant, while in the main group this figure was not significantly changed. Treatment with L−arginine is more effective at the first and second stages of primary open−angle glaucoma.
Key words: primary open−angle glaucoma, retinal nerve fibers layer thickness in the inferior quadrant, L−arginine.