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№2' 2016
NEPHROLOGYInternational Medical Journal, Vol. 22., Iss. 2, 2016, P. 53−56.
PATHOGENIC SUBSTANTIATION OF PHARMACOTERAPY IN NEPHROLOGY
Kharkiv National Medical University, Ukraine
Clinical manifestation of acute renal failure, its pathogenetic relationship with biochemical reactions in the kidney tissue, their functional activity and processes of self−regulation are featured. Regardless of the cause of acute renal failure, renal disease is characterized by common mechanisms, among which oxygen deprivation, disorders of acid balance and water−electrolyte shifts are of primary importance. Their pathogenetic interdependence leads to nephron damage. Under these conditions, the optimum is replacement therapy including dialysis or kidney transplant surgery. To achieve drug protection of the kidney in accordance with the clinical severity of the disease, the drugs of different pharmacological groups or combinations, providing symptomatic effect, are administered. Herewith, the means of pathogenetic therapy, which providing nonspecific metabolic effects, can protect the kidney under pathological conditions, are absent. The rational combination of these properties is possible in drugs with antihypoxic activity based on the antioxidant mechanism, which allows polytropic pharmacodynamics. This is confirmed by the literature and the results of the original research of the effectiveness of synthetic (sodium salt of poly−(2,5−dihydroxyphenylene)−4−thiosulfate acid) and plant (hofitol) antihypoxants in a model of renal pathology. Against this background, improving the tissue respiration of the renal parenchyma and restoration of blood supply to the kidneys due to the direct antihypoxic action of the drugs protects their excretory function and its sensitivity to the processes of self−regulation.
Key words: nephrology, pathogenetic pharmacotherapy, multilateral action, sodium poly−(2,5−dihydroxyphenylene)−4−thiosulfate acid, hofitol.