ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 23., Iss. 1, 2017, P. 39−42.
CLINICO-PATHOGENETIC SIGNIFICANCE OF HEMOSTATIC DISORDERS IN PREGNANT WOMEN WITH AUTOIMMUNE THYROIDITIS
Kharkiv Medical Academy of Postgraduate Education, Ukraine
Autoimmune thyroid diseases occupy an important place among pregnancy complications. Timely diagnosis of thyroid pathology in pregnant, especially its subclinical forms, as well as prevention and treatment reduce the incidence of diseases in pregnant and newborns. At present, great attention is paid to the problem of investigation of hemostasis system as an important link in thyropathy development. To define the features of changes in the system of hemostasis in pregnant with autoimmune pathology of the thyroid gland, we investigated the patients with euthyroidism, hypothyroidism and autoimmune hyperthyroidism. General clinical examination of patients was performed; main indices of the coagulation system were studied in the dynamics of gestation. The findings of the research suggest that all pregnant with thyroid pathology, especially with subclinical course, have changes in system of hemostasis. The patients with hypothyroidism and autoimmune hyperthyroidism are characterized by chronometric and structural hypercoagulation, which does not develop at physiological pregnancy of the respective terms of gestation. It manifests in pregnant with hypothyroidism by chronic DIC syndrome, and in pregnant with hyperthyroidism by subclinical DIC syndrome. Structural hypocoagulation is typical for pregnant with euthyroidism. The research findings indicate that pregnant with thyroid pathology have pathological activation of the hemostasis system, which is one of the causes of obstetric and perinatal complications. Development of pathogenetically substantiated methods of prevention and treatment of autoimmune thyropathy can reduce obstetric and perinatal complications.
Key words: pregnancy, autoimmune thyroiditis, hemostasis, hypercoagulation.