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№2' 2017
OBSTETRICS AND GYNECOLOGYInternational Medical Journal, Vol. 23., Iss. 2, 2017, P. 37−40.
THE STATE OF ENDOMETRIAL RECEPTORS AT HYPERPLASTIC PROCESSES IN PERIMENOPAUSAL WOMEN
Kharkiv National Medical University, Ukraine
Endometrium hyperplasia in patients of childbearing age is one of the causes for reproductive health aggravation. The diagnosis of endometrial hyperplasia is based on subjective morphological criteria of changes in the endometrium tissue. In the perimenopausal period the hormonal status of women undergoes profound restructuring. To determine the condition of the endometrium we examined the patients in the perimenopausal period with glandular and adenomatous hyperplasia. It was revealed that the condition of endometrial receptors in patients with diffuse glandular endometrial hyperplasia showed increased expression of progesterone receptor at increased or maintained level of expression of estrogen receptors. Expressed glandular hyperplasia against a background of preserved level of expression of estrogen receptors was characterized by a slight increase in the level of proliferation marker K−67. A distinctive feature of adenomatous hyperplasia was expression estrogen and progesterone receptors but the level of Ki−67 proliferation was negative. The women with hyperplastic processes in perimenopausal period have a certain level of proliferative activate nuclei of endometrial cells in the uterine mucosa due to the amount of cellular genetic material. Therefore, the use of diagnostic criteria for endometrial receptors assessment may help to predict the course of the disease and differentiated approach to choosing treatment strategy in patients with endometrial hyperplasia.
Key words: endometrial hyperplasia, progesterone receptors, estrogen receptors, proliferation markers.