International Medical Journal, Vol. 24., Iss. 1, 2018, P. 73−79.
THE STATE OF INTESTINAL MICROFLORA IN PATIENTS WITH SEBORRHEIC DERMATITIS
Kharkiv Medical Academy of Postgraduate Education, Ukraine
The multifaceted pathogenesis of seborrheic dermatitis (SD) necessitates the study of various aspects of this dermatosis. Intestinal dysbacteriosis is a pathological process, an additional link in the pathogenesis of various dermatoses (atopic dermatitis, acne, microbial eczema, vitiligo). The data on intestinal dysbacteriosis at SD are solitary, therefore the goal of the study was to study the basic qualitative and quantitative parameters of the intestinal microflora in 42 patients, depending on the type, severity and duration of SD, determining the degree of dysbiotic disorders. Standard bacteriological method of stool examination was used to assess the state of the intestinal microflora. The study revealed a significant decrease in the number of obligate bacteria: bifido− and lactobacillus (p < 0.05), aerobic E. coli typical (p < 0.05), hemolytic E. coli in some patients, increase in the number of facultative (saprophytic epidermal staphylococcus) and conditionally pathogenic bacteria (yeast−like Candida fungi, enterobacter, cytrobacter, p < 0.05) as compared to those in the control group. Dysbacteriosis of the large intestine was established in 78.6 % of patients (grade 1 −− 36.4 %, grade 2 −− 45.5 % and grade 3 −− 18.1 %). The dependence of the degree of microbiological disturbances (dysbacteriosis) of the intestine and the degree of severity of dermatosis was revealed. In the inflammatory type of the disease, the quantity of not only bifidobacteria and lactobacilli significantly decreased in the patients (79.3 and 82.8 %), but also E. coli typical (89.7 %), which significantly differed from those in patients with non−inflammatory type of dermatosis (38.5, 30.8 and 23.1 %, p < 0.05). The amount of E. coli lactose−negative and E. coli hemolytic insignificantly increased in patients with inflammatory SD (10.4 and 20.0 %) compared with those in patients with another type of dermatosis (0 and 7.7 %, p < 0.05). Analysis of the qualitative composition of the large intestine microflora, depending on the duration of the disease, revealed reduction in the amount of indigenous microflora and increase in contamination by conventionally pathogenic microorganisms with an increase in the duration of dermatosis over five years. The study shows the relationship between the clinical features of SD and violations of intestinal microbiocenosis.
Key words: seborrheic dermatitis, pathogenesis, microflora of the large intestine, dysbacteriosis.