ARCHIVE

The paper discusses the role of glycemia control during the development of cardio−vascular pathology. A strong relationship between glycemic control and a reduced risk of micro− and macrovascular complications of diabetes mellitus has been proven. The advantages of early intervention to control the glycemia have been demonstrated. Effective diabetes management is one of the main factors of slowing down and preventing the development of cardiovascular complications of diabetes.

The paper presents the research results on studying the features of inflammation mediators in the combined pathology, i.e. bronchial asthma and chronic obstructive pulmonary disease with concomitant arterial hypertension. It has been established that the deepening of inflammation was observed at the base of their comorbidity, and in the group of patients suffering from the asthma − chronic obstructive pulmonary disease − overlap syndrome with concomitant arterial hypertension, the maximal levels of eosinophilia and the content of leukotriene B4 in blood were found.

The article discusses the key issues of the dynamics of metabolic syndrome markers in traumatic disease in the patients with an increased body mass index and the performed systemic multivariate analysis of metabolic state, which made it possible to reveal the pronounced deviation of the integral index if compared to the control one both at the early period and for long−term examined patients, as well as to emphasize the significant role of metabolic disorders in pathogenesis of traumatic disease in the patients with polytrauma and an increased mass index.

The current published data on the complications after median sternotomy in the patients with various cardiac pathologies and the results of their own experience in a combined surgical treatment have been analyzed. The useful model for the implementation of sternorrhaphy has been described.

The work presents the results of treatment of the patients with dominant abdominal lesion during polytrauma. It was concluded that the reduced mortality in the affected category to a certain extent was associated with the stabilization of severe fractures of the pelvis, which allowed to achieve the hemostasis, to prevent the intensification of retroperitoneal hematomas and to timely carry out the surgeries in the internal organs of abdominal cavity and retroperitoneum, including the organs of the urogenital system.

The effect of cord blood stem cells transplantation in the patients with dilated cardiomyopathy on arrhythmia development has been analyzed. It has been proven that using the cord blood stem cells in treatment of the patients with dilated cardiomyopathy did not result in severe arrhythmia complications within the long−term time period.

A method has been developed for treating dermal burns by applying synthetic wound coatings and a combined solution, having the antibacterial and stimulating effect. The results indicated a positive effect on the course of wound process and the timing of epithelization and skin recovery.

The protocol of surgical interventions in acute cholangitis, in particular endoscopic, percutaneous, laparoscopic and open methods, is justified. The practice confirmed that in most cases, patients needed several surgeries.

The effects of Roux−en−Y gastric bypass and laparoscopic mini−gastric bypass on lipid metabolism in patients with morbid obesity were comparatively analyzed. The results indicated the effectiveness of bariatric surgery and the prevalence of mini−gastric bypass in normalization of the lipid profile in the patients with dyslipidemia and morbid obesity.

An overview of national and foreign publications devoted to contemporary ideas about the etiology and pathogenesis of placental insufficiency and fetal growth retardation, diagnostic methods, differential diagnosis, pharmacotherapeutic and non−pharmacological methods of treatment are presented. Recommendations on the pregnancy and labor management, indications for emergency delivery, as well as forecasts are provided.

Biomolecular markers were studied in 69 patients with endometrial hyperplasia (EH), who made up the main group, and 20 women without endometrial hyperplasia. To assess the molecular biological features of endometrial hyperplasia, the expression of the proliferation markers (Ki−67), apoptosis (p53), estrogen (ER−α) and progesterone (PGR) receptors was determined using the immunohistochemical method. It has been proven that the determination of biomolecular markers Ki−67, p53 and sex steroid hormone receptors, i.e. ER−α and PGR, allows not only the prediction of the endometrial hyperplasia course, but also the assessment of the treatment effectiveness. The immunohistochemical method makes it possible to reveal the risk groups for the recurrence of hyperplastic processes, the development of possible endometrial malignancy, and to promptly appoint the patients with surgical treatment.

The effectiveness of the in vitro fertilization procedure in the patients with no effect after laparoscopic treatment of progressive tubal pregnancy is assessed. The application of cryoextracts of placenta in the protocols of extracorporal fertilization was concluded to contribute to an increase in uterine pregnancies by 1,4 times.

The results of implementing the diagnostic laparoscopy of the patients with ovarian cancer of III−IV stages to determine the extent of malignant distribution, the ovarian tumor sampling for histological verification of the diagnosis, conducting an immunohistochemical study and providing the conditions for further intraperitoneal neoadjuvant chemotherapy are presented.

The results of the performed neoadjuvant chemotherapy according to the TC and TAC regimens in the patients with curable breast cancer are presented. The relationship between the severity of tumor regression and the regimen of neoadjuvant chemotherapy in these patients was found. It has been established that expression of topoisomerase II−alpha and beta−tubulin of class III genes should be considered as predictive and prognostic markers in the selection of pre−surgery treatment of locally advanced breast cancer along with the generally accepted standards.

The article presents the results of creating the database for children with paroxysmal disorders, residents of Kharkiv region of Ukraine. The expediency and prospects of this database have been shown.

In this article the results of immunoassay studies performed in the group of patients with focal scleroderma at the stage of aggravation before the treatment and after the end of therapy are presented. A significant increase in antibodies to native DNA has been established, which reflects the development of pronounced autoimmune responses. In the patients with dysfunctional thymus, the antibodies to P−protein and actin myofibrils of the thymic myoid cells were found, that indicated the formation of an immuno−endocrine dysfunction syndrome involving active T−lymphocyte clones, increased humoral sensitization and lymphocytotoxicity.

Article provides an overview of the national and foreign scientific reports, concerning the current possibilities of liver fibrosis diagnosis in the patients with chronic hepatitis C. The markers of liver fibrosis suggest an analysis of the levels of a number of biochemical parameters in the serum of patients. The peculiarities of complex tests and fibrous panels with the specified pathology from the prognostic and diagnostic points of view are highlighted.

The article is dedicated to comparative characteristic of the methods of early diagnosis of acute purulent bacterial meningitis, i.e. biological investigation of cerebrospinal fluid and blood serum of the patients and performance of polymerase chain reaction at system and local levels.