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№2' 2019

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 25., Iss. 2, 2019, P. 40−44.


ROLE OF HORMONE THERAPY IN TREATMENT OF EARLY BREAST CANCER IN PREMENOPAUSAL WOMEN


Sadchikova M. V., Syniavina L. V., Otchenash N. M.

Kharkiv Medical Academy of Postgraduate Education
Municipal Non−Profit Organization "Regional Center of Oncology", Kharkiv
The Medical Center "Eva", Kharkiv, Ukraine

A systematic analysis of available currently published data on the use of hormone therapy in treatment of breast cancer in premenopausal women has been carried out. The review includes the data of foreign authors published over the past 20 years. The statistics on breast cancer is provided. Its subtypes were determined with basis on the expression of specific cytokeratins, the relationship of various biological types with age and the disease course, as well as brief recommendations were given on treatment of biological subtypes of breast carcinoma and a new trend in the treatment of triple−negative tumors is specified. The stages of the milestones of breast cancer hormone therapy are presented. The findings of large randomized studies, comparing the results of different combinations of hormone therapy, as well as the role of luteinizing hormone agonists, i.e. releasing hormone in fertility preservation, the significance of the suppression of ovarian function are shown. The issues of patient management after completion of chemotherapy and the difficulty of differentiating between "true" and "temporary" (women who can recover the menstrual cycle) menopause are discussed, since the assessment of ovarian function markers will show the same results, that makes it difficult to choose the drugs for hormone therapy. The modern approaches to the use of hormone therapy in breast cancer in premenopausal women according to the latest recommendations of the international associations of medical oncologists are considered.

Key words: breast cancer, hormone therapy, premenopause.


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