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The effect of combination therapy with fosinopril, nebivolol and atorvastatin on the markers of chronic systemic inflammation and endothelial dysfunction in the patients with hypertension of the second degree in combination with chronic obstructive pulmonary disease of the grades I−II was studied.

Current data on the prevalence of concomitant bronchial asthma in the patients with COVID−19, its impact on the severity, frequency of hospitalizations, ventilation, duration of treatment and mortality in the patients with coronavirus infection have been presented. The main pathogenetic aspects of the comorbid course of bronchial asthma and COVID−19 have been considered.

Published reports on the problem of studying the possibilities and directions of pathogenetic therapy in tuberculosis infection have been analyzed. Pathogenetic therapy is an important stage in the comprehensive treatment of tuberculosis and it helps to accelerate the reversal of inflammation, restore adequate immune response, enhance reparative processes in the body, prevent the formation of severe residual changes, and prevent the adverse reactions to anti−tubercular medications.

Topical issues of assessing the nutritional status of the patient in palliative care have been considered. The algorithm of its uniform criteria, as well as the calculation of nutritional need in various patients have been presented. The plan for managing the incurable patients has been provided.

The problem of acute intestinal obstruction accompanied by enteral insufficiency syndrome has been considered. Endogenous intoxication is a pathogenetic link in the multiple organ failure development. In this case, the evident manifestation of endogenous intoxication indirectly indicates the failure of the intestinal barrier. In view of this, the analysis of hematological parameters of homeostasis is diagnostically important both for recording the occurring processes, and their forecasting. In the patients with acute intestinal obstruction, the development of enteral dysfunction causes septicotoxemia, the toxic and mediator components of which are detected on the background of stress immunodeficiency and act independently of each other.

The direct results of surgical treatment of the patients with mediastinal tumors using thoracoscopic access have been analyzed. The duration of surgical intervention and post−surgery hospital stay of the patients, frequency of spread of mediastinal neoplasms depending on the location have been estimated. The advantages of minimally invasive thoracoscopic removal of mediastinal tumors have been proven.

The problem of treatment of diaphyseal tibial fractures in the patients with overweight and obesity, having its own characteristics and difficulties, has been considered. It has been emphasized that today there are no clear algorithms for the treatment process in such patients, that leads to aggravation of their quality of life, prolongation of disability.

Changes in hemodynamics and body water sectors in the patients under the influence of urgent pathology of the abdominal cavity have been studied. New data on the features of fluid redistribution, which form adaptive changes in central and peripheral hemodynamics, as well as disrupt the pattern of transport and oxygen exchange on the background of previous pathological fluid loss in the patients with urgent pathology of the abdominal cavity have been presented.

Hormonal and biochemical parameters of women with polycystic ovary syndrome in combination with and without metabolic syndrome were comparatively analyzed. The data obtained indicate the presence of ovarian hyperandrogenism, which leads to an impairment of the central and peripheral mechanisms of steroidogenesis regulation. Hormonal secretion and biochemical parameters of women depend on clinical form of the disease. The patients with metabolic syndrome had moderate hyperprolactinemia, decreased somatomedin−C levels on the background of insulin resistance. In women with polycystic ovary syndrome without metabolic disorders, a moderate hyperandrogenism comes to the fore.

A review of the published reports over the past five years provides an insight of the problem of abnormal uterine bleeding in gynecological patients with thyroid pathology. The high prevalence and significant role of thyroid disease in etiology of such bleeding indicate the need to assess its condition in the complex of medical and diagnostic management.

The morphological features and state of endometrial receptors in hyperplastic processes have been studied. Therapeutic tactics is determined taking into account the tissue homeostasis and the receptor profile of the endometrium. It was found that the levels of the proliferation marker Ki−67, as well as the expression of estrogen and progesterone receptors could help in predicting the activity of hyperplastic process.

The results of research related to the study of biorhythmological status in mental and behavioral disorders of different genesis and the influence of heliogeophysical factors on them have been summarized and analyzed. It was found that helio− and meteorological factors, creating the conditions for the occurrence of pathological manifestations due to desynchrony, affected the exacerbation of most mental illnesses in certain seasons of the year and determine clear peaks of hospitalization of the patients depending on the pathology. Circadian dysfunction can also contribute to the development of mental disorders, aggravate clinical symptoms and affect them. Individuals with evening type of working capacity to a greater extent than those with morning and undifferentiated types demonstrated a reduced adaptability to environmental influences.

Peculiarities of self−perception in the persons with different variants of "bodily dysophria" have been analyzed. There are 13 main categories of distress. Each group of distress factors in "bodily dysphoria" has been generally described. These categories of distress have been presented in the context of frustration, anxiety and adversion.

A retrospective analysis of data on radiation studies performed in 1013 wounded and injured as a result of modern combat trauma in the hybrid war in Eastern Ukraine at the stages of medical evacuation was performed. The coefficients of need for the following studies have been offered: integral and specialized for each method of radiological diagnostics at the II, III, IV levels of medical care, which depends on the technical equipment of the medical institution and intensity of hostilities.

Possibilities of ultrasonography in determining the frequency, location and structure of thrombosis of the veins of the upper extremities in trauma patients within the pre− and postoperative period, as well as in assessing the frequency of thrombosis depending on the location of injuries using two−dimensional mode, color and energy Doppler mapping, pulse−wave Doppler, functional tests with compression have been demonstrated.