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The latest Congress of the European Society of Cardiology was held this year in Barcelona, Spain. More than 30 thousand participants were able to learn about the latest developments of cardiology, which were presented at Hot Line sessions of the Congress under the overall theme of «Innovation and Heart». Session 1 «Cardiovascular disease: novel therapies» showed the findings of investigation of the advantages of a new drug LCZ696 in treatment of chronic heart failure; the feasibility of intravenous iron preparations on identification of its deficiency; the use of Сolchicine in cardiac surgery. Session 2 «Coronary artery disease and lipids» covered the results of the use of Darapladib, Ivabradine, alirokumab, Rosuvastin. Session 3 «Heart failure: devices and interventions» presented a study on improving the design of drug−eluting stents, a comparison of the cost of management of patients with cardioverter−defibrillator randomized to use the technology of home monitoring. Session 4 «Myocardial infarction» acquainted with the results of percutaneous coronary intervention in patients with myocardial infarction, effects of Ticagrelor effects at pre−hospital and hospital stages, evaluation of the drug TRO40303. Session 5 «Coronary artery disease and atrial fibrillation» reported the data on perioperative statin therapy reducing atrial fibrillation, long−term results of short−term antiarrhythmic therapy after catheter ablation of atrial fibrillation, the effect of prednisolone and immunotherapy on patients with tuberculous pericarditis.

The review analyzes the recent literature data on evaluation of prognostic value of the parameters obtained by Holter ECG monitoring in stratification of the risk of sudden cardiac death in patients after myocardial infarction. The urgency of the problem is due not only to its prevalence, but also an opportunity for preventive interventions. According to Holter monitoring, in 85 % of cases the mechanisms of sudden cardiac death are ventricular tachycardia and ventricular fibrillation, other causes are bradyarrhythmia and asystole. Predictive value of LVP (late ventricular potentials) used for detection of high−resolution ECG monitoring is discussed. It is noted that despite the numerous studies on QT dispersion in patients with acute myocardial infarction, its predictive value has to be confirmed. The method of T−wave alternation is important for prediction of sudden cardiac death. A promising method in solving this problem is investigation of variability of heart rate and turbulence. The authors conclude about the need for further randomized studies to prove the predictive value of individual markers for risk stratification of sudden cardiac death.

The сoncept of cardiovascular risk is based on the idea about mutual interference between metabolic and cardiovascular factors, modulating the size of total or global risk of coronary events, mainly realizing the influence by means of the so−called adipocyte function. Fatty tissue is considered not only a basic energy depot of the organism but also an active auto−, para−, and endocrine organ releasing bioactive substances of peptide and non−peptide nature to the blood stream. Apelin is secreted by human adipocytes; due to this it is often considered to be аdipokine. Аpelin is a peptide identified as a ligand for angiotensin−like receptor−1 APJ that is mainly secreted by endothelial cells and adipocytes. Thus, some investigations specify reduction of reperfusion heart involvement due to the action of apelin, which can be related to antioxidant properties and confirmed by the studies of malonic dialdehyde in the heart and cardiomyocytes of rats. The question about the role of apelin in development of hypertrophic states of myocardium and diseases related to it is still unclear. Some observations specify that reduction of apelin level accompanies development of uremic status, but not development of myocardium diseases as such. Nevertheless, the role of apelin in development of cardiovascular diseases is impossible to eliminate. At present apelin is considered a potential marker of cardiovascular and metabolic risk, however its diagnostic and prognosis value has not been studied completely, which requires continuation of research in this area. Thus, investigation of apelin properties allows to suggest its role in forming a number of pathologic states of the cardiovascular system with concomitant pathology of the gastrointestinal tract, therefore requires continuation of further study.

Arterial hypertension is one of the commonest cardiovascular risk factor in Ukrainian population. The risk of forming and manifestation of angina, coronary insufficiency, myocardial infarction and sudden death is distinctly and impressively related to the antecedent level of both systolic and diastolic blood pressure. Thus, there is increasing evidence that efforts should be directed to preventing development and progression of arterial hypertension, although debate continues about antihypertensive drugs to be considered the best in different clinical situation. The authors report the data about Pilot Project on Arterial Hypertension in Ukraine during 2012−2014. The information concerning pharmacokinetics and pharmacodynamics of Amplodipine that should be considered on prescription of this medicine is analyzed. Common results about Amlodipine application in definite clinical cases are presented. Thus, at present dihydropiridine calcium channel antagonists with their metabolic neutrality, anti−ischemic and organ−protection properties are one of the most effective classes of antihypertensive medication for primary stroke prevention in arterial hypertension and are recommended as first order antihypertensive drugs in such clinical cases as left ventricular hypertrophy, silent atherosclerosis, angina pectoris, peripheral artery affection, isolated systolic hypertension in elderly patients and those with metabolic syndrome.

Diabetes mellitus is a global health and social problem. Most patients with non−insulin dependent diabetes are diagnosed hypertension. The most accessible method for diagnosing the condition of the vessels and heart in such patients is ultrasound. In order to identify informative indicators of ultrasonography of the heart and blood vessels at progression of their dysfunction at combination of diabetes and hypertension, 134 patients were examined. The established marker indicators were divided into three classes: the first distinguishes between normal and abnormal, the second the norm, arterial hypertension and diabetes, and the third one is increased in patients with diabetes. It is therefore advisable to use in clinical practice the analysis of the proposed indicators for evaluation of blood vessels and the heart in patients with arterial hypertension and, in particular, in combination with type 2 diabetes mellitus and different stages of carbohydrate metabolism compensation.

Mechanical jaundice is a syndrome developing as a result of a number of benign and malignant diseases of hepatopancreatoduodenal area causing bile out−flow disorders and characterized by cholemia and acholia. Correction of bile out−flow disorders under inefficacy of mini−invasive transpapillary interventions is carried out with the help of renewing and reconstructive interventions. In spite of some success in mechanical jaundice syndrome treatment it should be recognized that many important problems of surgery have not been solved yet. Thus, elaboration of new, more physiological ways of surgical treatment of patients with common bile duct impassability of non−neoplastic origin is necessary. The aim of our work was elaboration of biliodigestive anastomosis allowing preserving morphofunctional state of the duodenum and providing prevention of ascending reflux−cholangitis. Open bile flow correction according to the original method was done as the second stage of treatment in 5 patients with distal broaching stricture of common bile duct as well as under its glandular stenosis against a background of pseudotumor−like pancreatitis. After 180° laparotomic rotation of the initial area of jejunum and its carrying into the window of mesocolon, standard formation of choledochojejunoanastomosis according to A.A. Shalimov with plug on leading intestine and choledochojejunoanastomosis with Braun fistula were done. Besides lower the choledochjejunoanastomosis, in isoperistaltic direction, side−to−side jejunoduodenoanastomosis was formed with more distal plug on the discharging intestine. The necessary requirement to the anastomosis is absence of duodenal impassibility signs. The suggested isoperistaltic biliodigestive choledochojejunoanastomosis provides complete bile entrance into the duodenal lumen with its morphofunctional renewal preventing hemorrhagic complications; preserving anatomic nervous and vascular interconnections allowing preserving the motor activity of small intestine loop used for bile passage. The isoperistalsis principle of the used area of small intestine provides prevention of ascending reflux−cholangitis development.

Treatment of patients with severe ulcerative gastroduodenal bleeding is a significant problem of modern gastroenterology. Among the causes of peptic ulcer disease is disorder of the immune state of the organism, in which an important role is played by cytokines. To study the dynamics of the content of cytokines at blood loss of varying degrees caused by acute ulcerative gastroduodenal hemorrhage, the patients were examined preoperatively and on days 3, 7 and 14 after the surgery. The concentration of pro−inflammatory and anti−inflammatory cytokines in the blood was determined by ELISA. All patients had changes in the local and systemic levels of pro− and anti−inflammatory cytokines compared with healthy subjects. The findings of the study allow the conclusion about the imbalance of cytokine state, the severity of which depends on the severity of blood loss, and that surgery against a background of imbalance in basic conservative therapy does not lead to recovery and requires adequate cytokine therapy.

The literature on treatment and postoperative rehabilitation of patients with ectopic pregnancy is reviewed. It is stressed that the existing methods of treatment do not allow complete restoration of the anatomical and functional integrity of the fallopian tubes and ciliated secretory epithelium. One of the methods of substitution of the dead muscle cells of the fallopian tubes is stem cell therapy. When administered systemically to the circulation, mesenchymal stem cells repopulate selectively the foci of tissue injury regardless of the tissue type. When they are administered systemically in the bloodstream of recipient animals, immature cells implant different organs and tissues, differentiating into blood cells, adipocytes, cartilage cells, fibroblasts, myocytes. The main contenders for the role of stem cells in skeletal muscles are satellite cells. Satellite cells and their developmental precursors derived from somites are direct sources of muscle cells. Myogenic precursor cells contained in the bone marrow are earlier than satellite cells myogenic precursors. They are able to migrate and reach the vascular bed of connective tissue damage. Genetic modification of stem cells gives new impetus to development of cellular technologies and their introduction into clinical practice. Owing to the ability to overcome the genetic defect ex vivo and embedding the full gene into stem cells of the patient, it is possible to solve a number of problems, including overcoming the barrier of HLA−histocompatibility with allogeneic transplants. One of the major challenges to development of cell therapy is to provide conditions for survival of transplanted cells. Genetic modification can aid achievement of not only enhancement of vitality but also correct metabolic processes, enhance proliferative and differentiation potential of stem cells to direct their differentiation in the right direction. The ability of some types of stem cells to migrate directly (homing) to the focus of tissue destruction and tumor growth will allow to use them for delivery of therapeutic products and suicide gene.

Aquaporins (AQP), or water channels, are the family of integral proteins involved in transmembrane transportation of water in the tissues. Some of them, AQP 1, 3, 4, 8, 9, were found in the placenta and membranes of the human fetus. A significant expression of AQP is associated with pathology of fetal amniotic fluid. In pathological conditions such as preecsplampsia characterized by placental ischemia, changes in the functional activity and synthesis of ACP can be a major factor responsible for the changes in energy homeostasis. It is assumed that AQP 1, 3, 8, 9 are involved in regulation of amniotic fluid, the violation of their expression in the fetal membranes is associated with idiopathic polyhydramnion or oligohydramnion. High level of AQP 3 and 9 expression was revealed in the normal placental trophoblasts. Preeclampsia is not a pathology of the fetal water balance, thus increase in AQP 9 expression is due to the additional role of the protein. Molecular and functional AQP 9 expression is influenced by insulin, human chorionic hormone, human gonadotropic hormone, cyclic adenosine phosphate, cystic fibrosis transmembrane conductance regulator, clarifying the role of which is the subject of further research. Special attention should be paid to studying the relationship between pathological conditions of the placenta and AQP expression.

One of important problems of modern oncology is search for the signs and properties of kidney tumors, based on which one could predict the course of the disease and determine the appropriate treatment. In addition to the clinical stage, their essential characteristics are histological variant, the degree of differentiation and biological aggressiveness. Owing to advances in molecular biology, new key points of carcinogenesis and tumor cell parameters have become clear. Thus, the key role of interaction of tumor cells and stroma during tumor progression and metastasis is played by activation of matrix metalloproteinases. Investigation of MMP−9, type IV collagen, a marker of endothelial cells CD 31 and vascular endothelial growth factor VEGF in renal cell carcinoma can aid in establishing the characteristics of their expression in tumor thrombi, thus simultaneous analysis of the content of these antibodies in the tissue of the patients is important. One study have evaluated the role of micro−RNAs in development of tumor thrombi at clear−cell renal carcinoma analyzing the expression of miR−200c, miR−210, miR−126, miR−221, let−7b, miR−21, miR−143, miR−141. Their expression profile allowed the authors to create a classification system. The analysis of morphological parameters of renal cell carcinoma with macroscopic intravenous invasion is still one of the most important directions of oncourology development. This information will allow distinguishing the most important prognostic factors for patients with renal cell cancer, especially evaluation of the pathogenesis of intravenous tumor invasion and choice of the best technique for adjuvant therapy.

This paper analyzes the changes in drug therapy of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) over the recent five years. Currently, drug therapy strategy is based not only on correction of LUTS, hematuria or complications of BPH (urinary tract infection), but also on preventing disease progression. Tamsulosin is a selective blocker of the main alfa−1A−adrenergic receptors. New drugs, including Silodosin and Naftopidil have been introduced into clinical practice. Type 5 phosphodiesterase inhibitors also demonstrated high efficiency in correction both obstructive and irritation symptoms. It has been objectively established that type 5 phosphodiesterase inhibitors inhibitors did not affect the volume rate of urination. Currently, among the three drugs in this group (Sildenafil, Vardenafilum, Tadalafilun), only Tadalafilum 5 mg once a day has been officially licensed for treatment of male LUTS with or without erectile dysfunction. Sufficient amount of information about the long−term use of type 5 phosphodiesterase inhibitors, their influence on the size of the prostate and BPH progression has not been accumulated yet. As to the new areas of medical treatment of LUTS/BPH, the role of vitamin D receptor agonists and antagonists of growth hormone were described, as well as the results of the use of new types of combination therapy (Tadalafilum + 5A reductase inhibitors) were discussed.

Investigation of multiple sclerosis by modern neurology was started relatively recently, in the second half of the nineteenth century. This is a disease with marked clinical variability, unpredictable prognosis, unknown etiology and poorly understood pathogenesis. MS manifests by disorders of motor function, sensitive sphincter, intellectual mnestic disturbances, disorders of the organ of vision, autonomic dysfunction. MS is very common in young able−bodied persons who become disabled rapidly, making it a socio−economic problem. The prevalence of MS in Ukraine is 30 per 100 thousand, and an avalanche growth of MS with polymorphism of clinical manifestations complicating epidemiological and diagnostic investigations has been observed. In spite of the described difficulties, the literature data show that treatment of multiple sclerosis have been developed and implemented, although much remains unclear. The approach to evaluating the effectiveness of current treatment for MS is described. However, at present there are no clinical criteria that would allow predicting whether a particular drug is effective in each patient. None of the described drugs is sufficient to control the pathological process. Optimization of the schemes for diagnosis and treatment of MS, development of adequate, economically justified treatment algorithms at different stages of the disease are an important medical and economic task at present.

Hyperkinetic syndrome may be a manifestation of both infectious and somatic diseases in children, therefore it requires a careful examination. Hyperkinesis is considered a serious disorder in the activity of the brain. At this syndrome, neurotransmitter exchange is disturbed mainly in the structures of the extrapyramidal system. The clinical manifestations are associated with inflammatory processes in the basal ganglia and the caudal nuclei of the central nervous system. Depending on the level of brain damage, three groups of hyperkinesis, stem, subcortical, cortical−subcortical, are distinguished. In this work the different types of hyperkinetic syndrome, symptoms and signs, pathogenesis, features are characterized. Particular attention is paid to differential diagnosis, illustrated with a clinical example. An algorithm for examination of children with hyperkinesis, which will help early diagnosis and proper selection of therapy, was suggeted.

Cerebral circulation disorders are one of the most important problems of clinical neurology. In recent years, despite the large number of modern methods of diagnosis and treatment, increase of this disease, especially in people of productive age, has been noted. The purpose of the work was to study the clinical and neurological features of stroke in young people by means of the study of literature data and clinical examination of 2 patients who were hospitalized to Kharkiv Regional Hospital. The complexity of the problem of stroke in young people is due to lack of knowledge about this disease, poor population information about the first symptoms and their consequences, which ranks first among the causes of primary disability, and adverse social and economic situation. The interest in the study of clinical and neurological features of cerebral circulation disorders in young people is due to the fact that the etiology of stroke in young patients differs greatly from that in older patients and often remains unclear, which is important for prevention of recurrent episodes. At present an algorithm for treatment of young patients has not been developed sufficiently. This problem has great medical and social significance. The article presents the original observations of young patients after acute cerebral circulation disorders. The question of the causes, pathogenesis, clinical presentation and therapeutic tactics of cerebral circulation disorders in young people remains opened. The literature data allow us to conclude that, despite the challenges of modern medicine, there are many issues that require further study. The obtained results show that there are a number of problems, which are responsible for special presentation of cerebral circulation disorders in young adults

The aim of the study was to evaluate the brain−derived neurotrophic factor (BDNF) blood plasma levels in patients with subcortical vascular mild cognitive impairments (SVMCI) before and after escitalopram treatment. The study involved 22 patients with SVMCI, according to G.B. Frisoni et al. (2002) criteria and 16 age, sex and education level matched persons without cognitive impairments (WCI). Comparison groups included elderly and senile persons. BDNF blood plasma levels were evaluated by ELISA method in all enrolled persons at baseline and in 10 SVMCI patients 2 months after escitalopram therapy (10 mg per day). Clinical protocol included neuropsychological testing (Luria`s tests, MMSE and other valid approaches), psychopathological study (The Neuropsychiatric Inventory), neurological examination, disturbances in daily life activities study (The Bristol Activities of Daily Living Scale). It was shown that plasma BDNF levels decreased in group of SVMCI (25939.55±10410.46 pg/ml) versus the controls (31581.50±8092.29 pg/ml). Reduction of BDNF level had the highest correlation with some parameters of executive dysfunction: violation of active recall (r = 0.41, p < 0.05) and kinetic apraxia (r = 0.35, p < 0.05), reflecting the violation of the link between the prefrontal cortex and subcortical structures due to microvascular brain lesions in SVMCI group. Escitalopram treatment led to increased level of plasma BDNF in SVMCI (30066.00±10796.43 pg/ml) group. The increase in BDNF level was significantly related to the improvement in MMSE and The Neuropsychiatric Inventory scores of the patients. In conclusion, the reduction in BDNF blood plasma concentration can be used for validation of SVMCI diagnosis and its increase as a reliable marker of the therapy effectiveness.

The ideas about interaction of psychotrauma and specific reactivity has been repeatedly calling the attention of clinicians because of its occurrence and progression of neurotic register disorders. Given the noted increase in the prevalence of psychosomatic disorders, this issue is pressing in psychotherapy clinic, which have determined the purpose of the study. The article covers clinical−theoretical interpretation and systematization of psychotrauma as a fundamental component of psychotherapy clinic. It describes five levels of psychogenic disorders. The basic regularities of psychopathogenesis of these disorders depending on the level of development were determined. The role of psychogenia in formation of psychosomatic pathology was described. Psychological defense mechanisms characteristic of patients with psychosomatic diseases were considered and differentiated. It was noted that for the psychological defense mechanisms subjective awareness, characteristic of patients suffering from psychosomatic disorders, in contrast to the patients of neurological clinic, is less typical, whereas the levels of passivity and rigidity prevail. At the same time, a certain number of psychosomatic patients more often than neurotic patients present more flexible coping strategies. The authors conclude about the importance of systematization of the analyzed phenomena in the form of psychophenomenological profile to develop therapeutic strategies that are most appropriate to the nature and level of psychogenic disorders that can provide optimal timing and quality of psychiatric help.

Three hundred and eighty−two patients (76 with coronary artery disease, angina, 75 with coronary artery disease, myocardial infarction, 77 with transient ischemic attacks, 81 with cerebral stroke, 73 with gastric and duodenal ulcer) were examined to identify specific features of emotional−affective sphere of patients with acute conditions of somatic profile. Clinical psychopathological and psychodiagnostic investigation was done. It was found that the patients with acute medical condition of psychosomatic register were characterized by the presence of common features of emotional−affective sphere. Most patients with acute somatic diseases were characterized by absence of depressive symptoms. In case of high level of personal anxiety, as basic personality characteristic, the average level of reactive anxiety was in the range of moderate values, despite to the presence of objective threat to the individual vital existence. Combination of the average level of hostility and low levels of aggression, both motivational and general aggressiveness indicated presence of passive attitude to their condition, as well as interiorization of aggressive impulses in patients with acute medical diseases. The basis for development of pathogenetically substantiated system of medical and psychological correction of psychological deadaptation in patients with acute conditions of therapeutic profile should be the data of clinical, psychopathological and psycho−diagnostic examinations.

According to the Ministry of Health of Ukraine, the incidence of autism spectrum disorders (ASD) in Ukraine increased 3.8 times (from 2.4 to 9.1 per 100 000 child population) within the period of 2008−2013 due to improved diagnosis and active work to identify children with the problems of psychological development and adaptation. The prevalence of ASD has increased 3.5 times (from 13.8 to 48.2 per 100 000 child population) since 2008. Although autism is diagnosed in childhood, the problems associated with the disease are not limited to the period of childhood, and are transferred and persist in adulthood. The purpose of the work was to search for and create new programs to help the patients with autism spectrum disorders at different age stages in children, teen−agers, and adults. With the aim to orient and guide timely the parents with a sick child by a primary care physician into the specialists, the knowledge of modern service organization of psychiatric and psychological care of patients with autism is necessary. This knowledge should be obtained on the stage of postgraduate training. Psychiatrists making differential diagnosis at the stage of specialized care make the diagnosis of autism, plan a comprehensive treatment, including psychopharmacotherapy, psychotherapy, psychological correction and social rehabilitation. It is strategically important to ensure autistic children as well as adults with social assistance, educational programs, the organization of working conditions to allow the possibility of acquiring profession. Social rehabilitation should be maximally personalized in order to enable independent living. It is also necessary to prepare and publish educational materials and manuals, not only to raise awareness of the staff working with autistic persons, but also aimed at helping the patients with autism in education and employment. For correction of occurring disorders in adults with autism it is necessary to develop new therapeutic approaches and strategies of psychological input in the families of people with autism.

The aim of this study was to determine the dynamics of the retinal nerve fibers layer thickness in the inferior quadrant in patients with primary open−angle glaucoma (POAG), treated by L−arginine. The study involved 162 patients (287 eyes) with POAG. The study group consisted of 82 patients (146 eyes) who received basic therapy along with L−arginine (patent of Ukraine UA 52177 U). The control group included 80 patients with POAG (141 eyes) who received standard therapy. It was found that the frequency of stabilization the retinal nerve fibers layer thickness in the inferior quadrant was observed 1.5 times more frequently (65.1 %) compared with the control group (42.5 %, p < 0.05). The frequency of stabilization the retinal nerve fibers layer thickness in the inferior quadrant in patients with POAG significantly increased at the first stage (21.2 % vs. the control group, while in the second stage by 21.9 %. It was established that application of L−arginine in treatment of patients with POAG helped to stabilize the retinal nerve fibers layer thickness in the inferior quadrant. Thus, in the control group there was a significant decrease in the retinal nerve fibers layer thickness in the inferior quadrant, while in the main group this figure was not significantly changed. Treatment with L−arginine is more effective at the first and second stages of primary open−angle glaucoma.

The problem of seborrheic dermatitis (SD) has become increasingly important in dermatovenerology. A wide spread of SD in people of working age, constant increase in the incidence, psychoemotional disorders, decreased social activity and quality of life of patients, insufficient knowledge and divisiveness of some aspects of the pathogenesis, low efficiency of existing treatment dictate the need for further study of the mechanisms of dermatosis. Currently, a single point of view of the etiology and pathogenesis of SD does not exist. As possible factors contributing to the emergence of the disease, genetic predisposition, hormonal status changes, various neurotic disorders, diseases of the gastrointestinal tract, medication, the presence of bacterial flora, metabolic changes, pollution, nutritional and climatic factors (high ambient medium) and others are considered. These factors affect the secretion of sebum and break the barrier properties of the skin, which leads to proliferation and increase in the amount of previously saprophytic microorganisms Malassezia spp. and development of inflammation associated with impaired sebum discharge, keratinization, and itching. Immunodeficiency states, especially disorders of humoral (complement system proteins, antimicrobial peptides) and cellular (phagocytic cells, NK−cells, T−lymphocytes etc.), innate immune factors play a significant role in the pathogenesis of SD caused by activation of opportunistic flora. Of particular interest in development of the dermatosis is the study of vitamin D and its metabolites involved in immune (antimicrobial) protection the skin. The study of innate immunity, vitamin D metabolism in patients with SD will widen the idea about the pathogenesis and promote development of treatment.

The work covers the investigation of genetic polymorphism of endothelial growth factor VEGF in patients with nonscarring forms of alopecia for diagnosis and prognosis of the disease, and further development of differential treatment. The purpose of the work was to analyze the distribution of polymorphism of G (−634) C and G (−1154) A of VEGF gene in patients with nonscarring forms of alopecia. The study involved 105 patients with various forms of nonscarring alopecia aged 14−50 years. Of them, alopecia areata was present in 38 (36.2 %), androgenic in 56 (53.3 %), diffuse in 11 (10.5 %). Molecular genetic investigation was conducted at the Laboratory of Medical Genetics, Institute of Hematology and Blood Transfusion of Ministry of Health, Republic of Uzbekistan in 47 patients with alopecia of Uzbek population. For molecular genetic studies G (−634) C and G (−154) A gene of VEGF we developed a test system based on real−time polymerase chain reaction. The control group included 30 apparently healthy donors ethnic Uzbeks living in Tashkent. The results of analysis show that distribution of the incidence of mutant alleles and genotypes of polymorphism of G (−634) C and G (−1154) A gene VEGF in alopecia patients accounted for 8.8 % and 6.0%, respectively. In the control group, the corresponding figures were equal to 1.7 %. Allele A carrying heterozygous type of mutation of VEGF genotype at position G (−1154) A was revealed in 11.8 % of the patients with alopecia. In the controls, the persons carrying mutant allele accounted for 3.3 %. A method of testing polymorphisms of G (−634) C and G (−1154) A VEGF gene based on real−time PCR equal to foreign analogues was developed and tested. The observed distribution of heterozygous genotypes of both loci, reliably meet the expected law of Hardy−Weinberg. Due to the fact that the frequency of heterozygosity of polymorphism G (−634) C and G (−1154) A VEGF gene is not very high, their predictive value is low (AUC = 0.57 and 0.54, respectively) and requires further research in the broader range of the population.