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№4' 2013

CARDIOLOGY

International Medical Journal, Vol. 19., Iss. 4, 2013, P. 12−15.

CLINICAL INSTRUMENTAL AND GENETIC FACTORS AFFECTING THE LONG-TERM PROGNOSIS IN PATIENTS WITH CORONARY ARTERY DISEASE WHO UNDERWENT CORONARY ARTERY STENTING

Kharkiv Medical Academy of Postgraduate Education, Kharkiv City Clinical Hospital No. 8

Seventy−five patients were investigated to study clinical instrumental and genetic factors affecting the long−term prognosis at coronary artery disease. The complex examination of the patients included physical, clinical methods, a 6−minute walk test and genotype CYP2C19 study. Comparative analysis of the groups of patients was performed using Student's t−test for quantitative parameters. Depending on the disease course the patients were divided into groups with favorable and unfavorable prognosis. During the examination 33.3% of patients developed various complications necessitating hospital treatment. It was established that the factors associated with unfavorable course were low functional class of stable angina, high functional class of heart failure established prior to the intervention, the presence of genotype CYP2C19, and frequent alcohol intake in a dose exceeding 4 drink/day. The obtained findings should be considered when treating this group of patients.

Key words: stenting, prognosis, genotype CYP2C19, coronary artery disease.