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№2' 2013
HYGIENE, EPIDEMIOLOGY, MEDICAL ECOLOGYInternational Medical Journal, Vol. 19., Iss. 2, 2013, P. 116−120.
MEDICAL-TOXICOLOGICAL INVESTIGATION OF SUPERFICIALLY ACTIVE SUBSTANCES IN CONNECTION WITH THE PROBLEM OF SANITARY PROTECTION OF DRINKING WATER SOURCES
Kharkiv National Medical University, Kharkiv, Ukraine
Abstract. At present detergents are main component of domestic chemicals, therefore their invasion to the environment has acquired a global character. The purpose of this work was to make medical biological assessment of metabolism, toxicodynamics and toxicokinetics of detergents as well as to investigate the mechanisms of biological effect of nonionogenic, cation active, and anion active surface active agents (SAA) on the organism of experimental; animals. Twenty−five samples of SAA with given technical characteristics were chosen, the necessity of the choice was conditioned by a great volume of their production and extensive use in various areas of economy. It was established that the molecular mechanism of SAA biological effect consisted in primary disorder of structural organization of biological membranes of all inner organs, including genetic apparatus, followed by the changes in its function. Practical recommendations of prevention of the damaging effect of SAA were formulated.
Key words: superficially active substances, experimental animals, toxic biological action, prevention measures.