International Medical Journal, Vol. 24., Iss. 4, 2018, P. 81−84.
INDICATORS OF MELATONIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN PSORIATIC PATIENTS WITH SLEEP DISODERS
CPR "Urban Skin and Venereal Dispensary N4", Kharkov, Ukraine
Psoriasis is a chronic recurrent skin disease of multifactorial nature with immuno−mediated pathogenesis, in which inflammation and unbalanced angiogenesis are the key causes of manifestation of the disease in the form of characteristic erythematous−squamous rashes. The vascular endothelial growth factor (VEGF) is an anti−inflammatory marker that demonstrates endothelial dysfunction and pathological neoangiogenesis. Melatonin, the hormone epiphysis among many regulatory processes obtains anti−inflammatory and antiangiogenic functions. In order to determine the level of melatonin and VEGF in the blood of patients with psoriasis of varying degrees of severity of dermatosis and evaluation of these indicators, based on sleep disorders, 60 patients were examined. The definition of sleep quality was performed using a score assessment questionnaire for subjective sleep characteristics. A marked increase in the level of VEGF and a decrease in the level of melatonin in the blood of patients with psoriasis with the most significant deviations in the severe form of the disease was found. Correlation dependence of these indicators on the presence of sleep disturbances is established. The results obtained suggest that the clinical course of psoriasis and the quality of sleep depend on the imbalance of the prohangio−genic growth factor VEGF and the antiangiogenic factor of melatonin.
Key words: psoriasis, sleep loss, comorbidity, melatonin, VEGF.